ADME

The ADME Database provides the latest and most comprehensive data for structurally diverse compounds associated with known ADME properties, including human oral bioavailability, enzymes metabolism, inhibition and induction, transport, plasma protein binding and bloodbrain barrier.

The database includes data from peer-reviewed journal articles, patents, Clinical Pharmacology Biopharmaceutics Review(s) section of NDA submissions, product labels for recently approved drugs (from 2000 to date) and European Public Assessment Report (EPARs)

Designed for utilization by all researchers in the drug discovery field, the ADME Database is updated and upgraded to customers quarterly.
 

  Main Features

• Pharmacokinetic on healthy subjects and patients (renal, liver impairment, cancer …)
• Compartmental and non compartmental PK results
• Phenotyping (Extensive versus poor Metabolizers) and genotyping data
• DDIs retrieve from peer-reviewed journal articles, Clinical Pharmacology Biopharmaceutics Review(s) section of NDA submissions and European Public Assessment Reports (EPARs)
• Phase I, Phase II and Phase III enzymes kinetic data (Km, Vmax, IC50, Ki, KI, EC50, t1/2…)
• Kinetic data on HLM, hepatocytes, recombinant systems (baculovirus, lymphoblastoid, e. coli, yeast)
• Export to Excel, SD or text files
  
  Uses
  Researchers in drug discovery, DMPK and GMPK specialists use this unique database to:
• Improve decision-making during drug discovery and development
• Improve Hit to Lead selection ratio by designing a focused library of compounds for in silico or high throughput screening process
• Optimize PB/PK and/or PK/PD models
• Compare PK and metabolism of other marketed drugs in the same indication
• Chemical structures of preclinical, clinical and marketed drugs
• Compound descriptions including structure, name, synonyms, pharmaceutical codes, therapeutic class, calculated physicochemical parameters and SMILES
• Druggability assessments using graphical representation based on Lipinski/Weber rules
  
  Chemical Information
• Chemical structures of preclinical, clinical and marketed drugs
• Compound descriptions including structure, name, synonyms, pharmaceutical codes, therapeutic class, calculated physicochemical parameters and SMILES
• Druggability assessments using graphical representation based on Lipinski/Weber rules
   Bioactivity and Experimental Methods
• Detailed biological material descriptions (species, tissue, cell, expression systems, etc…)
• Experimental methods including binding, transport, enzymatic inhibition, metabolism, induction and pharmacokinetic data are fully described
• Reference to journals, patents, FDA reviews and links to PubMed and Espacenet
  
  Quality Controls
• All registered data updated regularly utilizing validated Glossaries/Thesauri
• Specialized quality control at every production step
• Databases updated and released every three months

 Top