The Global Pharmacology Space (GPS) Database is an extensive knowledge base containing quantitative biological activity data for major therapeutic drug targets including G-Protein Coupled Receptors, Kinases, Ion Channels, Proteases and Nuclear Receptors.
Each of the data points within Global Pharmacology Database includes:
- The ligand chemical structure
- The associated activity data
- A precise description of the experimental protocol associated with the activity measurement
- Thorough exploration of a wide range of potentially “druggable” target space within one environment
- Rapid access to prior knowledge for a particular chemical scaffold or therapeutic target allowing assessment of target selectivity and off-target effects
- Knowledge-driven hypotheses capabilities that drive better informed decisions during drug discovery
- Share experimentally derived profiles with project team members
- Activity arranged by in-vitro and in-vivo bioassay protocols with full description of experimental conditions
- Activity measurement available in original reported unit as well as in standardized parameter for comparison across values
- Ligands described by 2D molecular structure, smiles, physicochemical properties, with reported name or pharmaceutical code
- Links to publication or patent
- Links to external websites (SwissProt, GeneID, PDB)
- Target and chemical hierarchy
Providing a powerful environment for analysis of activity data, Global Pharmacology Database content is organized using Aureus Sciences' knowledge management platform with its controlled terminology and glossaries. The same platform also supports integration of proprietary data or third party data.
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