Articles on GPCR
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
09/18/2011 - Nature Chemical Biology
The determination of the D3 receptor structure and the challenge to the community to predict it enabled a fully prospective comparison of ligand discovery from a modeled structure versus that of the subsequently released crystal structure.
Design Strategies for Bivalent Ligands Targeting GPCRs
04/21/2011 - ChemMedChem
This Minireview focuses on the design of bivalent ligands recently described in the literature; discussing the choice of lead pharmacophore, the position and nature of the attachment point for linking the two pharmacophore units...
02/16/2011 - Br J Pharmacol.
Type-1 cannabinoid receptor (CB(1)) and its endogenous agonists belong to an ancient neurosignaling system that plays important functions in neurodegenerative and neuroinflammatory disorders like Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis.
G protein-coupled receptors: novel targets for drug discovery in cancer
01/10/2011 - Nat Rev Drug Discov.
Review of recent findings that present unexpected opportunities to interfere with major tumorigenic signals by manipulating GPCR-mediated pathways
10/31/2010 - Nature Medicine
CX3CR1 and CX3CL1 may represent attractive therapeutic targets in asthma.
Parkinson Disease Research in Doldrums
09/15/2010 - Gen Eng News
Discontinuation of PD Trial Highlights Hazards Inherent in Developing Drugs for This Indication.
| Day | News |
|---|---|
| October 2011 | |
| 4 | Studies Show PGE2 Receptor EP4 Exerts Protective Effects in Stroke that Can Be Boosted Pharmacologically |