Articles on ion channels
Exploring HCN channels as novel drug targets
11/18/2011 (web) - Nature Reviews Drug Discovery
HCN channels may offer excellent opportunities for the development of novel anticonvulsant, anaesthetic and analgesic drugs. This Review gives an up-to-date summary of compounds and discusses strategies to further explore the potential of these channels for therapeutic intervention.
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
03/16/2011 - Nature
Here we show that progesterone activates the sperm-specific, pH-sensitive CatSper Ca2+ channel.
NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity
02/06/2011 - Nature Neuroscience
Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity.
01/31/2011 - Prog Mol Biol Transl Sci.
Evidence suggests that mammalian brain nicotinic acetylcholine receptors (nAChRs), the heterogeneous family of ion channels, play a pivotal role in drug addiction.
Novel α3β4 Nicotinic Acetylcholine Receptor-Selective Ligands
10/27/2010 - J. Med. Chem.
We report the discovery and SAR of a novel class of compounds that bind to the α3β4 nAChR and have no measurable affinity for the α4β2 or α7 subtype.