Articles on Nuclear receptors
On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back
10/17/2011 (Web pub. date) - Traffic
In this review, we summarize the contribution of various chaperone components involved in the nuclear transport of GR and propose an updated model of its nuclear import and export.
PPAR-γ action: it's all in your head
05/05/2011 - Nature
These findings suggest an important role for brain PPAR-γ in obesity and have major implications for the clinical use of TZDs.
02/21/2011 - Cancer Res
Our findings suggest that ERRγ agonists may have applications in the treatment of breast cancer.
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
04/17/2011 - Psychoneuroendocrinology
The idea that the therapeutic action of antidepressants is mediated, at least in part, by restoring GR function, is consistent with studies showing that decreased GR function contributes to HPA axis hyperactivity and to the development of depressive symptoms.
Evolution of promiscuous nuclear hormone receptors : LXR, FXR, VDR, PXR, and CAR
03/01/2011 - Molecular and Cellular Endocrinology
A combination of functional and computational analyses has shed light on the evolutionary changes of NR1H and NR1I receptors across vertebrates, and how these receptors may have diverged from ancestral receptors that first appeared in invertebrates.
Origin and evolution of the ligand-binding ability of nuclear receptors
03/01/2011 - Molecular and Cellular Endocrinology
We discuss an alternative possibility that the ancestor was a ligand sensor, which would be able to explain the apparently contradictory data generated in previous models for the evolution of ligand binding in nuclear receptors.
The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor
01/28/2011 - The Journal of Biological Chemistry
Here we report the crystal structure of the ligand-free TR4 ligand binding domain, which reveals an autorepressed conformation.